Nrf2 modulation is a research area focused on studying the molecular pathways involved in activating the Nrf2 transcription factor. Nrf2 plays a key role in regulating the expression of antioxidant and detoxification enzymes, which are crucial for protecting cells from oxidative stress and maintaining cellular homeostasis. Modulating Nrf2 activity has potential therapeutic applications in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Researchers are exploring ways to activate or inhibit Nrf2 signaling to develop novel treatments for these conditions.